http://journal.iipch.org/ijcpch/issue/feed 2021-09-07T01:09:10+07:00 Bakhtiar bakhtiar@unsyiah.ac.id Open Journal Systems <p>journal description</p> http://journal.iipch.org/ijcpch/article/view/40 2021-09-07T01:09:10+07:00 Radita Kusumaningrum raditakusumaningrum@gmail.com Magdalena Sidhartani magda_sid@yahoo.com Ninung R D Kusumawati roseadhiani@yahoo.co.id

<p>Drug Induced Liver Injury (DILI) in children accounts for 1% of all reported drug adverse reactions, and approximately 20% of all cases of acute liver failure in children. Acute decline in liver function without a history of liver disease accompanied by hepatic encephalopathy is defined as Fulminant Hepatic Failure (FHF). Viruses, drugs, toxins, and various conditions such as cardiovascular and metabolic diseases can cause FHF. Hepatotoxicity associated with anti-Tuberculosis (TB) drugs has been reported in 5% -28% of people treated with anti-TB drugs. We present a case of a 15-year old girl with DILI, FHF and TB. Consumption of anti-TB drugs cause hepatocellular DILI which then lead to FHF. Patient was successfully treated and can finished 6 months TB treatment without any complaint after re-challenged.</p>

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