Drug Induced Liver Injury,  Fulminant Hepatic Failure and Tuberculosis  on 15-Year Old Girl: A Case Report

Radita Kusumaningrum; Magdalena Sidhartani; Ninung R D Kusumawati

Radita Kusumaningrum Department of Child Health, Faculty of Medicine, Diponegoro University / Kariadi Hospital, Semarang, Indonesia
Magdalena Sidhartani Department of Child Health, Faculty of Medicine, Diponegoro University / Kariadi Hospital, Semarang, Indonesia
Ninung R D Kusumawati Department of Child Health, Faculty of Medicine, Diponegoro University / Kariadi Hospital, Semarang, Indonesia

Keywords: Drug Induced Liver Injury, Fulminant Hepatic Failure, Tuberculosis

Abstract

Drug Induced Liver Injury (DILI) in children accounts for 1% of all reported drug adverse reactions, and approximately 20% of all cases of acute liver failure in children. Acute decline in liver function without a history of liver disease accompanied by hepatic encephalopathy is defined as Fulminant Hepatic Failure (FHF). Viruses, drugs, toxins, and various conditions such as cardiovascular and metabolic diseases can cause FHF. Hepatotoxicity associated with anti-Tuberculosis (TB) drugs has been reported in 5% -28% of people treated with anti-TB drugs. We present a case of a 15-year old girl with DILI, FHF and TB. Consumption of anti-TB drugs cause hepatocellular DILI which then lead to FHF. Patient was successfully treated and can finished 6 months TB treatment without any complaint after re-challenged.