The Differences of Pletelet Count, Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW) in Preterm Newborns with and without Patent Ductus Areteriosus (PDA)

  • Hana Christiani Sembiring Department of Pediatrics Adam Malik Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Muhammad Ali Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik Hospital, Medan, Indonesia
  • Pertin Sianturi Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik Hospital, Medan, Indonesia
Keywords: PDA, platelet, MPV, PDW

Abstract

Background : Patent ductus arteriosus is the most common congenital heart disease in premature newborns. The role of platelet in the closure of ductus arteriosus remains controversial.

Objective: To evaluate the difference of platelet count, MPV, and PDW in the premature newborn with and without PDA.

Methods: This was cross-sectional that collected from a medical record of the premature newborn who hospitalized in the Perinatology Unit of Adam Malik Hospital from November 2017 to September 2019. The diagnose of PDA was taken from echocardiography data. Platelet indices were found from the laboratory’s result that was performed in 24 hours of life.

 

Result: A total of 73 preterm newborns consist of 35 newborns with PDA and 38 newborns without PDA. There was a significant difference in platelet count in both groups which the mean of platelet count in PDA groups was  152,765.71/µl (SD 71,792.46) and in non-PDA groups was 274,456.05/µl (SD 121,360.88). However, there was no significant difference between MPV and PDW in both groups (P= 0.22, P= 0.79). We also found that low platelet mass index and low ratio RDW to platelet were related to PDA.

 

Conclusion: There is a significant difference in platelet count in preterm newborns with and without PDA which the mean platelet count in newborns with PDA was significantly lower than in newborns without PDA.

 

Keywords: PDA, platelet, MPV, PDW

Published
2021-01-01